In recent years, the Siena baseball program has become a top breeding ground for professional baseball prospects in the Northeast. Since 1996, 11 Saints have been drafted in Major League Baseball's first year players draft. In the spring of 2005, John Lannan became the latest Siena player to join the professional ranks after being drafted in the 11th round by the Washington Nationals. In 2004, two more Saints joined the professional ranks, as Ryan Bitter was selected in the 22nd Round by the Tampa Bay Devil Rays, and Blake Hanan signed on with the Baltimore Orioles Organization following the draft. In June of 2002, three Siena players were drafted--matching a program high. Dave Pahucki and Jim Buckley, both seniors, were chosen by the Boston Red Sox in the 23rd and 25th rounds respectively, while Justin Knoff, a junior, was picked in the 30th round by the Cincinnati Reds. In total 33 Siena players have gone on to sign professional baseball contracts with three (Billy Harrell, Gary Holle and Tim Christman) reaching the highest level.
| 1950 | Jim Sweeny - Boston Red Sox |
| 1952 | Billy Harrell - Cleveland Indians, Boston Red Sox; MVP Eastern League 1956. |
| 1955 | Jim Walsh - Brooklyn Dodgers |
| 1958 | Joe McCrudden - Brooklyn / L.A. Dodgers |
| 1976 | Gary Holle - 13th round by Milwaukee Brewers also w/ Texas Rangers, Chicago White Sox, Philadelphia Phillies |
| 1978 | Dave Smith - 30th round; New York Mets |
| 1982 | Ken Hayner - signed w/ Utica Blue Sox |
| 1983 | Jim Howard - 6th round; Baltimore Orioles |
| 1984 | Jim Howard - 23rd round; Toronto Blue Jays |
| 1984 | Larry Monaco - 29th round; Toronto Blue Jays |
| 1984 | Tom Winter - 24th round; Toronto Blue Jays |
| 1989 | Chris Alesio - signed w/ St. Louis Cardinals |
| 1989 | Chris Gorton - signed w/ St. Louis Cardinals |
| 1989 | Dave Howard - 24th round; Pittsburgh Pirates |
| 1989 | Shaun Sottile - signed w/ Atlanta Braves |
| 1990 | Pasquale Arace - signed w/ Pittsburgh Pirates |
| 1991 | Kevin Carroll - signed w/ New York Mets |
| 1992 | Mike Serbalik - 32nd round; L.A. Dodgers |
| 1994 | Dave Perry - signed w/ Ind. Catskill Cougars |
| 1996 | Tim Christman - 11th round; Colorado Rockies |
| 1996 | Ira Tilton - 5th round; Philadelphia Phillies |
| 1996 | Paul Wilders - 33rd round; St. Louis Cardinals |
| 1997 | Dennis Hogan - signed w/ Ind. Allentown Ambassadors |
| 1997 | Craig Johnson - 20th round; Detroit Tigers |
| 1997 | Mike Roberts - 21st round; Atlanta Braves |
| 1999 | Todd Donovan - 8th round; San Diego Padres |
| 1999 | Jeremy Giard - signed w/ Ind. Massachusetts Mad Dogs |
| 2000 | Kevin Brown - signed w/ Ind. Johnstown Johnnies |
| 2000 | Dave Fields - signed w/ Ind. Chillicothe Paints |
| 2000 | Nick Spera - signed w/ Ind. Nashua Pride |
| 2002 | Dave Pahucki - 23rd round; Boston Red Sox |
| 2002 | Jim Buckley - 25th round; Boston Red Sox |
| 2002 | Justin Knoff - 30th round; Cincinnati Reds |
| 2004 | Ryan Bitter - 22nd Round; Tampa Bay Devil Rays |
| 2004 | Blake Hanan - signed with Baltimore Orioles |
| 2005 | John Lannan - 11th round; Washington Nationals |
